IGHV1-18
Allele appearnce
The group of IGHV1-18 includes 4 alleles, 4 out of the alleles are functional.
For each allele we counted the number of appearances across the population, any appearance was considered valid. # no cutoff applied
Group alignment
Based on the viewd alleles, we calculated the distance between the germline sequences.
Sequence depth
To examine the potential cutoff we observed the sequence depth for each allele # fix jitter
0.5% cutoff
We set an initial cutoff of \(0.5\%\) to determine the potential genotype priors. For this cutoff we examined the zygousity state, such as homozygousity, heterozygousity and so on.
With the selected cutoff we saw that there are 3 zygousity states.
Observations
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From the results we belive that the cutoff for this group should be closer to \(12.5\%\), and for the adjusted states the allele combinations and the relations are stated in the table below.