The group of IGHV1-18 includes 4 alleles, 4 out of the alleles are functional.
For each allele we counted the number of appearances across the population, any appearance was considered valid. # no cutoff applied
Based on the viewd alleles, we calculated the distance between the germline sequences.
To examine the potential cutoff we observed the sequence depth for each allele # fix jitter
We set an initial cutoff of \(0.5\%\) to determine the potential genotype priors. For this cutoff we examined the zygousity state, such as homozygousity, heterozygousity and so on.
With the selected cutoff we saw that there are 3 zygousity states.
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## [1] TRUE
From the results we belive that the cutoff for this group should be closer to \(12.5\%\), and for the adjusted states the allele combinations and the relations are stated in the table below.